Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
2021 · paper · Clinical trials
A trial randomising 1,900 comatose adults after out-of-hospital cardiac arrest to cooling at 33°C or targeted normothermia. Death at 6 months was similar (50% vs 48%), and arrhythmia was more common with hypothermia.
1 finding
Substance Table 2 prints the normothermia arrhythmia rate as "152/921 (16)", but 152/921 = 16.50%, which rounds to 17, the figure given in the Abstract and Results ("24% vs. 17%").
- p. 9 Table 2, Arrhythmia resulting in hemodynamic compromise, Normothermia column
152/921 (16)
- p. 8 Results, Adverse Events
(in 24% vs. 17%; P<0.001)
- p. 1 Abstract, Results
(24% vs. 17%, P<0.001)
- p. 8 Adverse Events text
in 24% vs. 17%; P<0.001
Judge's note: I read the page 9 image of Table 2 and the page 1 and page 8 crops. 152/921 = 16.504%, which is above the midpoint, so this is not a rounding tie. The other table cells are rounded conventionally, not truncated (140/881 = 15.9 printed as 16; 87/881 = 9.9 printed as 10). The text and abstract say 17% for the same count, so the table cell is the inconsistent one.
Second check: another model agreed
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6 minor (typos and the like; most checked by the judge only)
Wording Methods: "score of <4 on the Full Outline of Unresponsiveness [FOUR] scale,12 which ranges from 0 to 4". The 0–4 range is the motor component, which Table 1 footnote ‖ correctly calls "FOUR motor scores range from 0 to 4".
- p. 2 Methods, Patients
score of <4 on the Full Outline of Unresponsiveness [FOUR] scale,12 which ranges from 0 to 4
- p. 5 Table 1 footnote ‖
Full Outline of Unresponsiveness (FOUR) motor scores range from 0 to 4
Only the authors can say what is right here.
Judge's note: Rests on outside knowledge: the full FOUR scale has four components scored 0–4 each, so the total runs from 0 to 16. Page 2 Methods and page 5 Table 1 footnote ‖ were checked in the crops. In the Methods the clause 'higher scores indicating better motor function' shows the motor subscale was meant, but the wording says 'FOUR scale' while Table 1 says 'FOUR motor score'. This is an imprecise label, not a wrong criterion.
Second check: another model agreed
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Wording Table 2 footnote * refers to "poor neurologic function at 6 months", but the row and Methods call this outcome "Poor functional outcome at 6 mo".
- p. 9 Table 2, footnote *
and poor neurologic function at 6 months were adjusted
- p. 9 Table 2, row label
Poor functional outcome at 6 mo‡
- p. 9 Table 2 footnote *
poor neurologic function at 6 months
Judge's note: Page 9 image: footnote * lists 'death from any cause, a modified Rankin scale score of 4 to 6, and poor neurologic function at 6 months', which corresponds to the 'Poor functional outcome' row. The Methods (main.txt line 228) define 'poor functional outcome'. This is a terminology inconsistency only.
Second check: another model agreed
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Typo Table 2 footnote ‡ ends with a doubled period, "These results are based on all available data..", and footnote † ends "struc-tured interview" with no period.
- p. 9 Table 2, footnote ‡
These results are based on all available data..
- p. 9 Table 2, footnote †
These results are based on data from a struc-tured interview
Judge's note: The page 9 image shows both punctuation slips as printed.
Second check: none (judge only)
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Typo "Charité Universitätzmedizin" (Disclosures, p. 10; affiliations, p. 11) is misspelled for Universitätsmedizin.
- p. 10 Disclosures paragraph (Dr. Leithner)
Charité Universitätz-medizin
- p. 11 Appendix, author affiliations (C. Storm, C.L.)
Charité Universitätzmedizin, Berlin, Germany
- p. 11 Affiliations
Charité Universitätzmedizin
- p. 10 Disclosures
Charité Universitätz-
Only the authors can say what is right here.
Judge's note: Rests on outside knowledge: the institution's name is Charité – Universitätsmedizin Berlin. The page 10 and page 11 crops both show the 'tz' spelling.
Second check: none (judge only)
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Typo Affiliations: "Skåne University Hospital Malmö, Malmö, (J. Düring, S.S., H.F.)" has a stray comma before the initials.
- p. 11 Affiliations
Skåne University Hospital Malmö, Malmö, (J. Düring, S.S., H.F.)
Judge's note: Page 11 crop. Other entries put the initials straight after the city with no comma, for example 'Halmstad (J.U.)' and 'Gothenburg (C.R., A. Lundin)'.
Second check: none (judge only)
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Typo Reference 19 reads "Vienna: Foundation for Statistical Computing, 2013", which is missing the 'R' of 'R Foundation for Statistical Computing'.
- p. 12 Reference 19
Vienna: Foundation for Statistical Computing,
- p. 12 Reference 19
Vienna: Foundation for Statistical Computing
Only the authors can say what is right here.
Judge's note: Rests on outside knowledge: R's publisher is the 'R Foundation for Statistical Computing'. The page 12 image shows ref. 19 as 'Vienna: Foundation for Statistical Computing, 2013.' with no R.
Second check: none (judge only)